Roman Cheplyaka
Wednesday 17 February 2021 : Polygenic risk scores (PRS) rely on the genome-wide association studies (GWAS) to predict the phenotype based on the genotype. However, the...
Wednesday 13 January 2021 : In this episode, we chat about phylogenetics with Xiang Ji. We start with a general introduction to the field and then go deeper into the...
Wednesday 16 December 2020 : In this episode, Markus Schmidt explains how seeding in read alignment works. We define and compare k-mers, minimizers, MEMs, SMEMs, and...
Wednesday 18 November 2020 : In this episode, Jacob Schreiber interviews Devin Schweppe about the analysis of mass spectrometry data in the field of proteomics. They...
Wednesday 07 October 2020 : In this episode, Jacob Schreiber interviews David Kelley about machine learning models that can yield insight into the consequences...
Thursday 10 September 2020 : In this episode, Jacob Schreiber interviews Jill Moore about recent research from the ENCODE Project. They begin their discussion with an...
Wednesday 19 August 2020 : In systems biology, Boolean networks are a way to model interactions such as gene regulation or cell signaling. The standard interpretations...
Wednesday 29 July 2020 : In this episode, Jacob Schreiber interviews Marinka Zitnik about applications of machine learning to drug development. They begin their...
Wednesday 27 May 2020 : In this episode, I continue to talk (but mostly listen) to Sergey Koren and Sergey Nurk. If you missed the previous episode, you should...
Wednesday 20 May 2020 : In this episode, Sergey Nurk and Sergey Koren from the NIH share their thoughts on genome assembly. The two Sergeys tell the stories behind...
Wednesday 29 April 2020 : Porcupine is a molecular tagging system—a way to tag physical objects with pieces of DNA called molecular bits, or molbits for...
Friday 27 March 2020 : Will Townes proposes a new, simpler way to analyze scRNA-seq data with unique molecular identifiers (UMIs). Observing that such data is not...
Monday 27 January 2020 : Kris Parag is here to teach us about the mathematical modeling of infectious disease epidemics. We discuss the SIR model, the renewal...
Monday 30 December 2019 : Does a given bacterial gene live on a plasmid or the chromosome? What other genes live on the same plasmid? In this episode, we hear from...
Friday 29 November 2019 : In this episode, Benjamin Callahan talks about some of the issues faced by microbiologists when conducting amplicon sequencing and...
Tuesday 22 October 2019 : In this episode, Luke Anderson-Trocmé talks about his findings from the 1000 Genomes Project. Namely, the early sequenced genomes sometimes...
Friday 30 August 2019 : In this episode, we hear from Romain Lopez and Gabriel Misrachi about scVI—Single-cell Variational Inference. scVI is a probabilistic...
Friday 26 July 2019 : Even though the double-stranded DNA has the famous regular helical shape, there are small variations in the geometry of the helix depending...
Saturday 29 June 2019 : An αβ T-cell receptor is composed of two highly variable protein chains, the α chain and the β chain. However, based only on bulk DNA or...
Friday 31 May 2019 : Modern genome assembly projects are often based on long reads in an attempt to bridge longer repeats. However, due to the higher error rate...
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Roman Cheplyaka
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